Paul Leufkens, PharmD, MBA
CEO and co-founder
Paul holds MSc and PharmD degrees from Utrecht University and obtained his MBA at Bradford University (UK). Over the past 15 years he has spun out a variety of technologies from University-based research groups. He was a co-founder of AM-Pharma (acquired by Pfizer in 2015), Neurophyxia and Trajectum Pharma, and held senior positions in product development at Exponential Biotherapies Inc. (Washington, DC), Reliance Life Sciences (Mumbai, India) and Pharming (Leiden). Earlier in his career Paul worked in clinical development with Sanofi and Yamanouchi Europe.
Frebus van Slochteren, MSc, PhD
CTO and co-founder
Frebus received his PhD degree in April 2014, defending his thesis entitled “Technical solutions to improve cardiac regenerative therapy”. He is also the inventor (together with Dr. Chamuleau) of the Company’s first patent, filed in April 2014 entitled: “Cardiac imaging processing for interventions” based on the work for his PhD thesis and which is now part of CART-Tech’s core technology. He obtained his MSc degree in Control Systems Engineering from the University of Hertfordshire, and in Medical Engineering of the Eindhoven University of Technology. Per April 2018 Frebus is full-time member of the CART-Tech MT.
Johan Maas, MSc
VP Marketing & Sales (consultant)
Johan obtained his degree in Medical Sciences from Groningen University and has worked at Medtronic from 2000 to 2015 in a variety of sales and marketing positions in the cardiac rhythm management division of Medtronic, and has significant hands-on experience with the introduction of CRT devices in several EU markets.
Ninke van der Werk, MSc
Quality & Regulatory Affairs Officer
Trained as a technical designer (MSc in Industrial Design Engineering, Delft University of Technology), Ninke developed herself as a QA/RA specialist. She has extensive expertise in the design and development of medical devices, set-up and maintenance of Technical Files, requirements engineering, product and process risk management, usability engineering, quality management system development and implementation, auditing, training, and coaching.
She has extensive (> 10 years) experience with safety critical design and quality assurance throughout the entire development life cycle of medical devices, including the CE marking process and regulatory submissions in Canada and Australia. Her background is in software and hardware for active medical devices in different areas of the medical field (dialysis, insulin infusion, radiology, radiotherapy).
Pieter Kuppens, MSc
Senior Software Engineer
Pieter is a driven Software Professional and Data Scientist and holds a MSc degree in Mathematics and a PDEng in Information and Communication Technology, both from the Eindhoven University of Technology.
He has been working in High Tech (ASML, Mapscape), Finance (ABN AMRO), and what has become his niche, Healthcare (Philips, Isatis Health, Nemo Healthcare).
With his interest and experience in Artificial Intelligence, he focuses on implementing Deep Learning techniques for the automatic segmentation of cardiac tissue images.
Daan Baas, MSc, PhD
Senior Software Engineer
Daan is a strongly motivated and experienced software engineer. He earned his PhD degree in Cognitive Neuropsychiatry for fMRI brain research at Utrecht University and obtained his MSc degree in Cognitive Neuroscience from Groningen University. Since 2008 Daan has worked as a software engineer and teamlead for several video (Vidigo, United Broadcast Facilities) and medical (Brain Science Tools, Brain Carta, MILabs, 3mensio) software companies. Daan loves medical imaging technology and is grateful to work on innovations that help clinicians and surgeons perform novel and more precise interventions.
Emanuele Rondanina, MSc, PhD
Application Software Engineer
Emanuele is a biomedical engineer with a PhD in cardiovascular mechanics. He is deeply passionate about developing software technologies that enable smooth and efficient clinical decision making. His academic experience started at the University of Genoa, continued at the Royal Institute of Technology in Stockholm and concluded at the Eindhoven University of Technology. There he was selected as a Marie Skłodowska-Curie fellow for the project “MUSICARE” (MUltiSectoral Integrative approaches to CArdiac caRE). During his fellowship, he developed two modelling tools to predict short- and long-term outcomes of cardiac diseases, generating new insights on cardiac growth and remodelling. In September 2020, he defended his PhD thesis, entitled “Strategies to model cardiac growth”. At CART-Tech, he is working as an Application Engineer, working along with software engineers and physicians to improve image guided therapies.
Prof. Steven Chamuleau, MD, PhD
Is a cardiologist and head of department of Cardiology at the Amsterdam University Medical Centers (Amsterdam UMC, the Netherlands), specialized in cardiac regenerative therapy, valvular disease and cardiac imaging. He combines state-of-the-art cardiac care with promising experimental techniques and tries to implement new strategies and techniques in the pre-clinical as well as the clinical phase. As both a clinician and PI, Steven is well known for his translational work and vision.
He finished medical school in Amsterdam and subsequently received his PhD degree cum laude in 2001 on intracoronary derived physiological parameters for clinical decision making at the Academic Medical Center (AMC) in Amsterdam under supervision of Prof. Jan Piek and Prof. Jan Tijssen. After his PhD he started his residency at the AMC Amsterdam, where he also did his fellowship training in cardiology and cardiac imaging. After a year in Louisville, KY, USA in the lab of the renowned Prof. Bolli, focusing on cardiac stem cell treatment, he received a position as a staff cardiologist at the UMC Utrecht (2008-2019) were he became deputy head of the department, and supervisor for the specialisation Cardiology.
Prof. Chamuleau has published over 160 peer-reviewed papers and is an active member in the Dutch and European Society of Cardiology, and scientific advisory board of the Dutch Heart Foundation, and the International Society of Cardiovascular Translational Research (ISCTR). He is a reviewer for many cardiac journals, such as EHJ and Circulation. At the moment he is a (co-)PI in several large international research consortia and clinical trials, primarily focused on stem cell treatmet, and valvular disease. He manages a large group of PhD Students, and became Professor of Cardiology at UMC Utrecht in 2016, and since 2020 in Amsterdam UMC.