Prof. Paul Gründeman, PhD, Spacemaker Champion

Paul Gründeman (1952), Senior researcher, Professor Beijing PLA medical School, Beijing, China and Associate Professor Experimental Cardiothoracic and Vascular Surgery, University Medical Center Utrecht, the Netherlands.
Dr. Gründeman’s research focuses on innovations in the field of cardiovascular diseases and the development of novel devices in this field. He has extensive experience in experimental cardiovascular surgery, especially in the field of minimal invasive technologies.
He is co-inventor of the Octopus® tissue stabilizer, which was developed for (closed-chest) beating heart coronary surgery and is currently marketed by Medtronic Inc.
In 2012, he initiated a collaboration with DSM, a Dutch based multinational company, for the development of a minimally invasive novel deployable heart valve for life made of Dyneema Purity® fibers.
Currently, as an inventor of the Spacemaking devices which facilitate the maneuverability for endoscopic instruments, he is leading the preclinical development in co-operation with Maastricht Instruments B.V.
For minimal invasive surgery he invented a suction-operated cutting device that creates a delineated controlled opening in blood vessels or access in other remote tissues protecting the underlying structures.
Paul is a physician with a background in cardiothoracic and vascular surgery and he has a Master in extracorporeal circulation. He holds a PhD in circulatory support in the failing pig heart. Paul has authored > 100 publications and is an inventor of 21 patents.

Paul Gründeman


Ye Gao, MSc, QA Officer

Ye joined CAR-Tech in August 2016 as a QA Officer. She received her bachelor’s degree in pharmacy from Changchun University followed by a Master degree in Biomedical Science from the University of Leuven (Belgium) in 2015.


Filippo Brogi, MSc, Senior Software Engineer

Filippo joined CART-Tech in November 2014 as a fulltime senior software engineer. He obtained a MSc Degree in Automation and Controls from the University of Siena (Italy). Before joining CART-Tech, he gained a lot of experience designing and  developing software for leading companies in the aeronautic field in Italy and in the Netherlands, working on multiple projects from project initiation through implementation, integration and testing.

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René van Es, MSc, PhD

René received his degree in Technical Medicine from the University of Twente in 2012, focusing on improving the process of stem cell homing by increasing the accuracy of intramyocardial injections with a special focus on multimodality imaging. Currently René is currently working as a PhD-student in the group of Dr. Chamuleau at the Department of Cardiology at UMC Utrecht in the and is primarily focusing on improving cardiac regenerative therapy and the development of novel cardiac ablation technologies.

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Thijs van den Broek, MSc

Thijs graduated as a medical engineer at the Technical University of Twente in 2015 and is currently working on his thesis on “Novel image guided intramyocardial injection techniques” in the research group headed by Dr. Steven Chamuleau at the Department of Cardiology at UMC Utrecht. He is working on future prototypes of CART-Tech’s CARTBox2 product.

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